--Shipping in two weeks, first come first serve

GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.

We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.

Benefits:

  • Live mice in stock and ready to ship in as soon as two weeks
  • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.
  • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

In-stock List (valid through October 10, 2022)

KO & cKO Mice

Strain ID Targeted Gene Strain Type Background Genotype Application

T012747

Sting1

Cas9-KO

C57BL/6JGpt

Homozygous

Viral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy

T010873

Nlrp3

Cas9-KO

C57BL/6JGpt

Homozygous

Innate immunity, inflammatory response

T010437

Gsdmd

Cas9-KO

C57BL/6JGpt

Homozygous

Pyroptosis, inflammatory response

T005534

Ifnar1

Cas9-KO

C57BL/6JGpt

Homozygous

Viral infection, inflammatory response, oncology-immunity

T050827

Gpx4

Cas9-cKO

C57BL/6JGpt

Homozygous

Ferroptosis, oncology, degenerative diseases

T011566

Shank3

Cas9-KO

C57BL/6JGpt

Homozygous

Synapses, autism

T009627

Piezo1

Cas9-cKO

C57BL/6JGpt

Homozygous

Tactile perception, ion channels

T011801

Uox

Cas9-KO

C57BL/6JGpt

Homozygous

Hyperuricemia, gout, uric acid nephropathy

T008338

Aars2

Cas9-cKO

C57BL/6JGpt

Heterozygous

Mitochondrial alanyl-tRNA synthetase, mitochondrial diseases, etc.

T008876

Cd36

Cas9-cKO

C57BL/6JGpt

Heterozygous

Lipid uptake, immune recognition, inflammation, molecular adhesion and apoptosis, etc.

T012963

Spp1

Cas9-cKO

C57BL/6JGpt

Heterozygous

Cancer, injury response, inflammatory response, etc.

T013205

Fgl1

Cas9-cKO

C57BL/6JGpt

Heterozygous

Immune checkpoint,autoimmunity, metabolic regulation, etc.

T006659

Mettl3

Cas9-cKO

C57BL/6JGpt

Heterozygous

M6A modification, cancers, etc.

T029037

Zbp1

Cas9-KO

C57BL/6JGpt

Heterozygous

Inflammatory response, necroptosis

T007446

Cxcl10

Cas9-KO

C57BL/6JGpt

Homozygous

Immune regulation, autoimmunity, viral infection, cancer, etc.

T007208

Cxcl10

Cas9-cKO

C57BL/6JGpt

Heterozygous

Immune regulation, autoimmunity, viral infection, cancer, etc.

T003676

Alkbh5

Cas9-KO

C57BL/6JGpt

Heterozygous

Reproduction(Male), epigenetic regulation, cancer, etc.

T006112

Ccr2

Cas9-KO

C57BL/6JGpt

Heterozygous

Cancer, autoimmune diseases, nervous system diseases, bacterial and viral infections, bone remodeling and metastasis, etc.

T008644

Csde1

Cas9-cKO

C57BL/6JGpt

Heterozygous

Cancer proliferation and inhibition, neural development, cardiac development, etc.

T013987

Trex1

Cas9-KO

C57BL/6JGpt

Heterozygous

Immune regulation, autoimmune diseases, DNA repair and replication, DNA degradation and apoptosis, etc.

T015624

Hnrnpa2b1

Cas9-KO

C57BL/6JGpt

Heterozygous

RNA processing, antiviral signaling pathway, etc.

T052147

Yap1

Cas9-cKO

C57BL/6JGpt

Heterozygous

Hippo signaling pathway, development, growth, repair and endogenous homeostasis, cancer, etc.



Cre Mice

Strain ID Targeted Gene Strain Type Background Genotype Application

T006205

Lrat-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Hepatic stellate cells

T004711

Adipoq-P2A-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: White adipose tissue, brown adipose tissue

T004714

H11-Vil1-iCre-ployA

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Gut epithelial cells

T004858

Myh6-CreERT2

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Almost all mature cardiomyocytes

T050182

Rosa26-SA-CreERT2

Cas9-KI(Rosa26)

C57BL/6JGpt

Homozygous

Expression system/tissue: Whole body (low activity in brain and skeletal muscle)

T004818

Cd4-iCre

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Helper T cells (CD4+ T cells)

T009409

H11-Stra8-iCre

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells

T004985

Lyve1-IRES-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed.

T005680

H11-Nphs1-iCre

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Expressed system/tissue: genitourinary system; Theoretically labeled cell type: glomerular, renal podocytes; no cellular level validation performed.

T006187

Cspg4-CreERT2

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed systems/tissues: circulatory system (other), nervous system (supporting cells); Theoretically labeled cell type: perivascular and glial cells; no cellular level validation performed.

T006208

Ptf1a-P2A-CreERT2

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: digestive system (see strain information for details). Theoretically labeled cell type: pancreatic tissue; no cellular level validation performed.

T004712

H11-Cdh5-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: vascular endothelial cells

T006185

Gcg-IRES-CreERT2

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: endocrine system (see strain information for details). Theoretically labeled cell types: islet alpha cells, intestinal endocrine cells, some neurons; no cellular level validation performed.

T004857

H11-Gfap-iCre

Cas9-KI(H11)

C57BL/6JGpt

Heterozygous

Expressed system/tissue: nervous system (supporting cells); see strain information for details. Theoretically labeled cell type: astrocytes of the central nervous system; no cellular level validation performed.

T004734

H11-Col1a1-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: motor system, skeletal system (see strain information for details). Theoretically labeled cell types: osteoblasts, corneal, tendon and other phorocytes rich in collagen; no cellular level validation performed.

T006202

Calb1-P2A-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed.

T006768

Cx3cr1-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Expressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed.

T050183

Rosa26-EIIA-iCre

Cas9-KI(Rosa26)

C57BL/6JGpt

Heterozygous

Expressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed.

Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.

Please let us know the genes you're interested in, and you will receive free email alert if we have any in-bank live mouse or a strain recovery plan.