--Shipping in two weeks, first come first serve

GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.

We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.

Benefits:

  • Live mice in stock and ready to ship in as soon as two weeks
  • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.
  • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

In-stock List (valid through Jan 10, 2023)

KO & cKO Mice

Strain ID Targeted Gene Strain Type Background Genotype Application

T012747

Sting1

Cas9-KO

C57BL/6JGpt

Homozygous

Viral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy

T010873

Nlrp3

Cas9-KO

C57BL/6JGpt

Homozygous

Innate immunity, inflammatory response

T010437

Gsdmd

Cas9-KO

C57BL/6JGpt

Homozygous

Pyroptosis, inflammatory response

T005534

Ifnar1

Cas9-KO

C57BL/6JGpt

Homozygous

Viral infection, inflammatory response, oncology-immunity

T009627

Piezo1

Cas9-cKO

C57BL/6JGpt

Homozygous

Tactile perception, ion channels

T011801

Uox

Cas9-KO

C57BL/6JGpt

Homozygous

Hyperuricemia, gout, uric acid nephropathy

T008876

Cd36

Cas9-cKO

C57BL/6JGpt

Heterozygous

Lipid uptake, immune recognition, inflammation, molecular adhesion and apoptosis, etc.

T006659

Mettl3

Cas9-cKO

C57BL/6JGpt

Heterozygous

M6A modification, cancers, etc.

T029037

Zbp1

Cas9-KO

C57BL/6JGpt

Heterozygous

Inflammatory response, necroptosis

T013987

Trex1

Cas9-KO

C57BL/6JGpt

Heterozygous

Immune regulation, autoimmune diseases, DNA repair and replication, DNA degradation and apoptosis, etc.

T015624

Hnrnpa2b1

Cas9-KO

C57BL/6JGpt

Heterozygous

RNA processing, antiviral signaling pathway, etc.

T002624

Nfe2l2

Cas9-CKO

C57BL/6JGpt

Heterozygous

Oxidative stress, inflammatory reaction, reproduction, etc.

T002625

Nfe2l2

Cas9-KO

C57BL/6JGpt

Heterozygous

Oxidative stress, inflammatory reaction, reproduction, etc.

T006005

Stat1

Cas9-KO

C57BL/6JGpt

Heterozygous

IFN signal pathway, cell proliferation and tumor related research

T008740

Hmgcs2

Cas9-cKO

C57BL/6JGpt

Homozygous

Ketosomatic synthesis abnormality, metabolic disorder

T011802

Pah

Cas9-KO

C57BL/6JGpt

Homozygous

Phenylketonuria, phenylalanine metabolism abnormality

T017208

Ticam1

Cas9-KO

C57BL/6JGpt

Heterozygous

Innate immunity

T052437

Il33

Cas9-KO

C57BL/6JGpt

Heterozygous

Inflammation, allergic disease, reproductive aging

T011361

Fabp4

Cas9-KO

C57BL/6JGpt

Heterozygous

Metabolism related research, etc.



Cre Mice

Strain ID Targeted Gene Strain Type Background Genotype Application

T004711

Adipoq-P2A-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: White adipose tissue, brown adipose tissue

T004714

H11-Vil1-iCre-ployA

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Gut epithelial cells

T050182

Rosa26-SA-CreERT2

Cas9-KI(Rosa26)

C57BL/6JGpt

Homozygous

Expression system/tissue: Whole body (low activity in brain and skeletal muscle)

T004818

Cd4-iCre

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Helper T cells (CD4+ T cells)

T009409

H11-Stra8-iCre

Cas9-KI(H11)

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells

T004985

Lyve1-IRES-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed.

T006208

Ptf1a-P2A-CreERT2

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: digestive system (see strain information for details). Theoretically labeled cell type: pancreatic tissue; no cellular level validation performed.

T004712

H11-Cdh5-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Theoretically labeled cell type: vascular endothelial cells

T004857

H11-Gfap-iCre

Cas9-KI(H11)

C57BL/6JGpt

Heterozygous

Expressed system/tissue: nervous system (supporting cells); see strain information for details. Theoretically labeled cell type: astrocytes of the central nervous system; no cellular level validation performed.

T006202

Calb1-P2A-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Expressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed.

T006768

Cx3cr1-iCre

Cas9-KI

C57BL/6JGpt

Homozygous

Expressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed.

T050183

Rosa26-EIIA-iCre

Cas9-KI(Rosa26)

C57BL/6JGpt

Heterozygous

Expressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed.

T004830

H11-Dmp1-iCre

Cas9-KI

C57BL/6JGpt

Heterozygous

Theoretically labeled cell type: Dentin cells, osteoblasts, bone cells; No cellular level validation performed.

T052715

Tyr-CreERT2

Cas9-KI(H11)

C57BL/6JGpt

Heterozygous

Theoretically labeled cell type: melanoblasts and melanocytes;No cellular level validation performed.

Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.

Please let us know the genes you're interested in, and you will receive free email alert if we have any in-bank live mouse or a strain recovery plan.