--Shipping in two weeks, first come first serve
GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.
We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.
Benefits：
- Live mice in stock and ready to ship in as soon as two weeks
- Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.
- Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.
In-stock List (valid through October 10, 2022)
KO & cKO Mice
| Strain ID | Targeted Gene | Strain Type | Background | Genotype | Application |
|---|---|---|---|---|---|
|
Sting1 |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Viral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy |
|
|
Nlrp3 |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Innate immunity, inflammatory response |
|
|
Gsdmd |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Pyroptosis, inflammatory response |
|
|
Ifnar1 |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Viral infection, inflammatory response, oncology-immunity |
|
|
Gpx4 |
Cas9-cKO |
C57BL/6JGpt |
Homozygous |
Ferroptosis, oncology, degenerative diseases |
|
|
Shank3 |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Synapses, autism |
|
|
Piezo1 |
Cas9-cKO |
C57BL/6JGpt |
Homozygous |
Tactile perception, ion channels |
|
|
Uox |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Hyperuricemia, gout, uric acid nephropathy |
|
|
Aars2 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Mitochondrial alanyl-tRNA synthetase, mitochondrial diseases, etc. |
|
|
Cd36 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Lipid uptake, immune recognition, inflammation, molecular adhesion and apoptosis, etc. |
|
|
Spp1 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Cancer, injury response, inflammatory response, etc. |
|
|
Fgl1 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Immune checkpoint，autoimmunity, metabolic regulation, etc. |
|
|
Mettl3 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
M6A modification, cancers, etc. |
|
|
Zbp1 |
Cas9-KO |
C57BL/6JGpt |
Heterozygous |
Inflammatory response, necroptosis |
|
|
Cxcl10 |
Cas9-KO |
C57BL/6JGpt |
Homozygous |
Immune regulation, autoimmunity, viral infection, cancer, etc. |
|
|
Cxcl10 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Immune regulation, autoimmunity, viral infection, cancer, etc. |
|
|
Alkbh5 |
Cas9-KO |
C57BL/6JGpt |
Heterozygous |
Reproduction(Male), epigenetic regulation, cancer, etc. |
|
|
Ccr2 |
Cas9-KO |
C57BL/6JGpt |
Heterozygous |
Cancer, autoimmune diseases, nervous system diseases, bacterial and viral infections, bone remodeling and metastasis, etc. |
|
|
Csde1 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Cancer proliferation and inhibition, neural development, cardiac development, etc. |
|
|
Trex1 |
Cas9-KO |
C57BL/6JGpt |
Heterozygous |
Immune regulation, autoimmune diseases, DNA repair and replication, DNA degradation and apoptosis, etc. |
|
|
Hnrnpa2b1 |
Cas9-KO |
C57BL/6JGpt |
Heterozygous |
RNA processing, antiviral signaling pathway, etc. |
|
|
Yap1 |
Cas9-cKO |
C57BL/6JGpt |
Heterozygous |
Hippo signaling pathway, development, growth, repair and endogenous homeostasis, cancer, etc. |
Cre Mice
| Strain ID | Targeted Gene | Strain Type | Background | Genotype | Application |
|---|---|---|---|---|---|
|
Lrat-iCre |
Cas9-KI |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: Hepatic stellate cells |
|
|
Adipoq-P2A-iCre |
Cas9-KI |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: White adipose tissue, brown adipose tissue |
|
|
H11-Vil1-iCre-ployA |
Cas9-KI(H11) |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: Gut epithelial cells |
|
|
Myh6-CreERT2 |
Cas9-KI(H11) |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: Almost all mature cardiomyocytes |
|
|
Rosa26-SA-CreERT2 |
Cas9-KI(Rosa26) |
C57BL/6JGpt |
Homozygous |
Expression system/tissue: Whole body (low activity in brain and skeletal muscle) |
|
|
Cd4-iCre |
Cas9-KI(H11) |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: Helper T cells (CD4+ T cells) |
|
|
H11-Stra8-iCre |
Cas9-KI(H11) |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells |
|
|
Lyve1-IRES-iCre |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed. |
|
|
H11-Nphs1-iCre |
Cas9-KI(H11) |
C57BL/6JGpt |
Homozygous |
Expressed system/tissue: genitourinary system; Theoretically labeled cell type: glomerular, renal podocytes; no cellular level validation performed. |
|
|
Cspg4-CreERT2 |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed systems/tissues: circulatory system (other), nervous system (supporting cells); Theoretically labeled cell type: perivascular and glial cells; no cellular level validation performed. |
|
|
Ptf1a-P2A-CreERT2 |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: digestive system (see strain information for details). Theoretically labeled cell type: pancreatic tissue; no cellular level validation performed. |
|
|
H11-Cdh5-iCre |
Cas9-KI |
C57BL/6JGpt |
Homozygous |
Theoretically labeled cell type: vascular endothelial cells |
|
|
Gcg-IRES-CreERT2 |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: endocrine system (see strain information for details). Theoretically labeled cell types: islet alpha cells, intestinal endocrine cells, some neurons; no cellular level validation performed. |
|
|
H11-Gfap-iCre |
Cas9-KI(H11) |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: nervous system (supporting cells); see strain information for details. Theoretically labeled cell type: astrocytes of the central nervous system; no cellular level validation performed. |
|
|
H11-Col1a1-iCre |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: motor system, skeletal system (see strain information for details). Theoretically labeled cell types: osteoblasts, corneal, tendon and other phorocytes rich in collagen; no cellular level validation performed. |
|
|
Calb1-P2A-iCre |
Cas9-KI |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed. |
|
|
Cx3cr1-iCre |
Cas9-KI |
C57BL/6JGpt |
Homozygous |
Expressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed. |
|
|
Rosa26-EIIA-iCre |
Cas9-KI(Rosa26) |
C57BL/6JGpt |
Heterozygous |
Expressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed. |
Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.
Please let us know the genes you're interested in, and you will receive free email alert if we have any in-bank live mouse or a strain recovery plan.