Adherens Junction
Akt/PI3 Kinase
Alzheimer's disease
AMPK pathway
Angiogenesis
Apoptosis Inhibition
Apoptosis(Overview)
ATP Related Chromatin Remodel
Autophagy
B Cell Receptor signaling
Cell Intrinsic Innate Immunity
Cell Cycle G1/S
Cell Cycle G2/M
Cell Extracellular Matrix and EMT
Cell Soluble Factors and EMT
Crosstalk PostTrans
Death Receptor
DNA Methylation
Dopamine Parkinsons
Epigenetic Histone H2A/H2B/H4
Epigenetic Histone H3
ErbB/HER Signaling
ES pluripotency and Differentiation
Glutamine metabolism
Hedgehog
Hippo Signaling
Histone Methylation
Hypoxia
Immune Cell Markers(Human)
Immune Cell Markers(Mouse)
Immune Checkpoint in TME
Inflammasome
Insulin Receptor
Jak/Stat:IL6 Signaling
MAPK/ERK in Growth and Differentiation
MAPK/ERK and G_Protein
MAPK_p38
mTOR
Necroptosis
NF-κB Signaling
Notch Signaling
Nuclear Receptor
Phosphoinositide lipid signaling
Phospholipase
Protein Acetylation
Protein Kinase C Signaling
Pyroptosis
Regulation of Actin
SAPK/JNK Signaling
T Cell Receptor
TGF-β Signaling
Toll Like Receptor Signaling
Translation：eIF2
Translation：eIF4
Translation（Overview）
Tumor Angiogenesis
Ubiquitin Proteasome
Vesicle Trafficking
Warburg Effect
Wnt ß-catenin Signaling
Epigenetic Histone H2A/H2B/H4
Histones are proteins abundant in lysine and arginine that packaged DNA into nucleosomes. These nucleosomes are the basis of tightly formed chromatin. Histones protect DNA from becoming damaged and getting tangled, and they play a critical role in gene regulation and in DNA replication. Of the five known histones, histone 2A (H2A), histone (H2B), and histone (H4) are considered core particles. In epigenetics, modifications to histones play a key role in controlling chromatin structure and gene transcription.
The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.
