ErbB/HER Signaling

The ErbB receptor tyrosine kinase family has four cell surface receptors: ErbB1/EGFR/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4. ErbB receptors signal through Akt, MAPK, and many other pathways to regulate cell proliferation, motility, migration, cell differentiation, and apoptosis. Given that ErbB receptors can be over-expressed, amplified, or mutated in various types of cancer, researchers are interested in them as therapeutic targets.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.