This pathway is activated when the body or cells have limited oxygen. The pathway is mediated by hypoxia-inducible factor (HIF). Under hypoxic conditions, HIF is stabilized and translocated into the nucleus. Once in the nucleus HIF binds to HIF1B, which increases the transcription of HIF target genes.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.