MAPK/ERK and G_Protein

GPCRs are the largest group of integral membrane proteins involved in cellular signaling. They are activated by various external stimuli including growth factors, neurotransmitters, and hormones. Once activated GPCRs can activate the MAPK/ERK signaling cascade.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.