NF-κB Signaling

Nuclear factor kappa B (NF-kB) is a protein transcription factor that regulates innate immunity. Given that NF-κB is an inducible transcription factor, once activated it can activate transcription of genes that regulate inflammation.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.