Regulation of Actin

Remodeling of the actin cytoskeleton is a dynamic and critical part of most cellular activities (e.g., cell shape, migration, proliferation, and survival). It is influenced by various signaling cascades that include G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins. Actin can transition between two forms, monomeric and filamentous. This transition is highly regulated by a number of signaling, scaffolding and actin-binding proteins (ABPs). When actin remodeling malfunctions, it can result in various human diseases.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.