SAPK/JNK Signaling

Stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) activation is critical for organogenesis to occur during mouse development. It regulates cell survival, apoptosis, and cell proliferation. There are two SAPK/JNK activators worth mentioning, SEK1 and MKK7. These are required to fully activate SAPK/JNK signaling, which responds to various stimuli.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.