TGF-β Signaling

Transforming growth factor-β (TGF-β) are a family of secreted polypeptide factors that regulate many aspects of adult tissue homeostasis and embryogenesis. TGF-β receptors are known to signal through the canonical SMAD pathway, which controls the expression of genes, and several non-canonical pathways that regulate various processes including cell polarity and microRNA maturation. The TGF-β family members are also involved in pathophysiological mechanisms that underlie many diseases.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.