GemPharmatech has focused on generating mouse models for four types of spontaneous tumors that are frequently identified in human patients: pancreatic cancer, hepatobiliary cancer, breast cancer and colorectal carcinoma. Find the Spontaneous tumor mouse models you need below.

Tumors are excessive accumulation of bodily mass, including solid tissue and fluid. Cancer is the overgrowth of solid mass, which can be benign or malignant. With the advance of cancer biology, our understanding of the driving forces of tumorigenesis has increased substantially. Accumulating evidence suggests that many types of tumors are results of spontaneous mutations in genes or the genome. Many of such mutations are somatic and not passed from the affected individual to his or her offspring. Through GWAS analyses, genes and genetic hot spots for mutagenesis have been identified. For example, in a 2017 study (1), 93% and 72% of pancreatic cancer patients are found to have acquired spontaneous mutations in KRAS and TRP53, respectively. Despite gender difference in cancer occurrences, two out of the top four most frequently diagnosed cancer types are the same in males and females: lung & bronchus and colon & rectum are #2 and #3, while prostate and breast cancers are #1 for men and women, respectively. Given the genetic similarities between humans and mice, murine strains carrying genetic mutations mimicking human disease genes have proven to be a valuable tool for studying disease mechanism and the development of therapeutic interventions.  

 

Tumor Type 

Model 

Genetic Background 

Genetic Mutation 

Availability Status 

Colorectal 

Apc-min 

C57BL/6J 

Apc PM 

√ 

Depending on the tissue specificity of the Cre 

Kras-LSL-G12D 

C57BL/6J 

Kras conditional PM 

√ 

Global 

Kras-KO 

C57BL/6J 

Kras knockout 

√ 

Depending on the tissue specificity of the Cre 

Kras-flox 

C57BL/6J 

Kras conditional knockout 

√ 

Depending on the tissue specificity of the Cre 

P53-LSL-R172H 

C57BL/6J 

Trp53 conditional PM 

√ 

Global 

P53-KO 

C57BL/6J 

Trp53 knockout 

√ 

Depending on the tissue specificity of the Cre 

P53-flox 

C57BL/6J 

Trp53 conditional knockout 

√ 

Depending on the tissue specificity of the Cre 

B6-KP 

C57BL/6J 

Kras and Trp53 double conditional PM 

√ 

Pancreatic with matastasis in multiple organs 

KPC 

C57BL/6J 

Kras, Trp53 double conditional PM with Pdx1-Cre 

√ 

Hepatobiliary cancer in presence of Alb-Cre 

B6-CAG-LSL-hMYC 

C57BL/6J 

hMYC conditional knockin 

√ 

Breast 

MMPV-PyMT 

FVB/NJ 

MMPV-PyMT random transgene 

√ 

Liver cancer in the presence of Alb-Cre 

Atg7-flox 

C57BL/6J 

Atg7 conditional knockout 

2022 Q3 

Melanoma in the presence of K18-Cre 

Braf-V584E 

C57BL/6J 

Braf conditional PM 

2022 Q3