Basic Information

Strain Name B6/JGpt-Lepem1Cd25/Gpt
Strain Number T001461
Official Symbol Lep,ob
Official Full Name leptin
Also Known As ob,obese
NCBI Number 16846
Research Areas Muscle respiratory system , adipose tissue , Cell Proliferation , Cell death , DNA transcription , reproductive system , digestive/alimentary system , Protein metabolism , Glucose metabolism , liver/biliary system , Diabetes model , renal/urinary system , Obesity model , Physiological system , endocrine/exocrine glands , homeostasis/metabolism , behavior/neurological , cell differentiation , Cell biology , Molecular biology , Metabolic research , Developmental Biology , cellular , embryo , growth/size/body , hematopoietic system , limbs/digits/tail , mortality/aging , Cell localization , Lipid Metabolism , immune system , integument , DNA binding protein , cardiovascular system , Disease and Drug Evaluation Model , Metabolic model , Tumor research , nervous system , Signal Transduction , skeleton , vision/eye
Strain Background C57BL/6JGpt
Modification Type Knockout (KO)
Genotyping Protocols -
Related Links NCBI: 16846
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Product Status

Inventory Status Live , Cryopreserved
Sale Status Available for Distribution
Health Status Specific pathogen free (SPF)

Published Literature

Name of Document URL
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity https://doi.org/10.1016/j.cmet.2021.02.007
Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo https://doi.org/10.1002/advs.202000818
Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms https://doi.org/10.1039/C9FO02283J
Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model https://doi.org/10.1016/j.lfs.2020.118966
Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging https://doi.org/10.1021/acs.analchem.1c00498
Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner https://doi.org/10.1096/fj.202000300R
Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer https://doi.org/10.1111/cas.15311
MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake https://doi.org/10.1038/s41467-022-31317-0
Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer https://doi.org/10.1002/advs.202203357

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