Basic Information

Strain Name BKS-Leprem2Cd479/Gpt
Strain Number T002407
Official Symbol Lepr,db
Official Full Name leptin receptor
Also Known As LEPROT,Leprb,Modb1,OBRGRP,Obr,db,diabetes,obeselike,obl
NCBI Number 16847
Research Areas -
Strain Background C57BLKS/JGpt
Modification Type Knockout (KO)
Genotyping Protocols -
Related Links NCBI: 16847
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Product Status

Inventory Status Live , Cryopreserved
Sale Status Available for Distribution
Health Status Specific pathogen free (SPF)

Published Literature

Name of Document URL
Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo https://doi.org/10.1002/advs.202000818
Purβ promotes hepatic glucose production by increasing Adcy6 transcription https://doi.org/10.1016/j.molmet.2019.11.008
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation https://doi.org/10.1155/2021/6617816
CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis https://doi.org/10.1016/j.biomaterials.2021.120963
A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis https://doi.org/10.1016/j.ebiom.2020.103202
circRNA_010383 acts as a sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy https://doi.org/10.2337/db20-0203
Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging https://doi.org/10.1021/acs.analchem.1c00498
Cdk5-mediated phosphorylation of Sirt1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy https://doi.org/10.1089/ars.2020.8038
High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy https://doi.org/10.1038/s41419-021-03502-4
Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds https://doi.org/10.1186/s13287-020-02116-5
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice https://doi.org/10.1016/j.metabol.2021.154768
Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy https://doi.org/10.1016/j.biopha.2021.111780
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism https://doi.org/10.1016/j.cmet.2020.11.017
VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy https://doi.org/10.2337/db21-0205
Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus https://doi.org/10.1016/j.freeradbiomed.2021.08.240
Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation https://doi.org/10.1016/j.apsb.2021.11.017
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin https://doi.org/10.1080/15548627.2021.1974175
A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice https://doi.org/10.1016/j.bbrc.2022.07.031
Hepatic leptin signaling improves hyperglycemia by stimulating MAPK phosphatase-3 protein degradation via STAT3 https://doi.org/10.1016/j.celrep.2022.111053
Inulin-Type Fructans Change the Gut Microbiota and Prevent the Development of Diabetic Nephropathy https://doi.org/10.1016/j.phrs.2022.106367
Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice https://doi.org/10.1016/j.phymed.2022.154316
Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome https://doi.org/10.1016/j.phymed.2022.154308

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