Mouse transplantation tumor model

Mouse transplantation tumor models are widely used in preclinical anti-tumor drug efficacy tests. Based on the donor and recipient resources, mouse transplantation tumor models can be divided into two categories.
1. Allograft transplantation model
In this model,mouse-derived tumors are inoculated into mice which can be used for screening immunoregulatory drugs. Note that, mice need to have the normal immune system, and have the same background as the tumor cells.
2. Xenograft transplantation model
In this model,human-derived tumors are inoculated into immunodeficient mice which can be used for screening chemotherapy drugs and targeted drugs. Based on the different transplated types, it can be furtherly divided into CDX (cell line-derived xenograft) and PDX (patient-derived xenograft).

CDX

The cell line-derived xenograft (CDX) model is well-recognized and commonly used in the development of anti-tumor drugs. Due to the user-friendly technology and excellent repeatability of this model, it is also widely used in the early stage of in vivo study.Cancer cells are usually inoculated into immune-deficient mice subcutaneously, or intravenously.

Advantages

  1. Numerous Cell Line-Derived Xenograft (CDX) Tumor Models 
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  1. Tumor orthotopical inoculation technology for brain tumor,  breast cancer, hepatic carcinoma, pancreatic cancer, etc.
  2. Tumor biomarker databank
  3. Imaging system to monitor tumor growth
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Data support

Growth curve of leukemia cancer cell HL-60

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Growth curve of leukemia cancer cell K562

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Growth curve of Leukemia cancer cell MV-4-11

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Growth curve of breast cancer cell BT474

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Growth curve of ovary cancer cell SK-OV-3

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Growth curve of breast cancer cell MDA-MB-231

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Growth curve of colorectal cancer cell HCT-116

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Growth curve of colorectal cancer cell Lovo

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Growth curve of pancreatic cancer cell BxPC-3

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Growth curve of pancreatic cancer cell SW1990

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Growth curve of prostate cancer cell PC-3

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Time:2019-12-10