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KOAP Webinar KOAP Webinar

KOAP - Your Rich Mouse Model Library

June 29, 2021 1st broadcast:KST 20:00, EDT 07:00 | 2nd broadcast: PDT 12:00, EDT 15:00

Speakers: Hongyu Wang, PhD, Mark Moore, PhD, CEO and Pradeep Kumar Sacitharan, PhD

Genetically modified animal models have been widely used in biomedical research and pharmaceutical R&D. Gene targeted mice are crucial for identifying gene function and deciphering disease mechanisms.

GemPharmatech is proud to launch the Knockout All Project (KOAP) , which aims to build a resource library of conditional knockout and knockout models for more than 22,000 of all protein coding genes in the mouse genome. This effort draws upon GemPharmatech’s strong R & D capability, which allows us to produce over 6,000 new mutant strains annually. With the phase I launch of KOAP, we have completed constructing more than 16,000 mouse lines using CRISPR/Cas9 technology. We are now launching phase II, which presents a wonderful opportunity to match your research needs with our ever-growing resources.

In the upcoming webinar, we will share experience-based insights to show our KOAP plan. Focusing on the following parts:

  1. GemPharmatech’s improvement on genome editing efficiency
  2. What is KOAP
  3. Why can KOAP help facilitate your research

For more information, please contact sales@gempharmatech.us

Metabolic Symposium Webinar (Obesity) Metabolic Symposium Webinar (Obesity)

Innovations in phenotyping for Obesity, Diabetes and Comorbidities

The mouse has been a pivotal model organism for biological discovery for more than a century, with historical references for mutant mice with dominant spotting reach back to China in 1100 B.C.E. Most recently, with the first identification of the obese ob/ob mouse strain in 1949, tremendous advances have been made in creating and breeding mouse strains that reflect human diseases, both by conventional breeding methods as well as genetic engineering methods.

Global efforts to generate genetically modified mice libraries by using methods such as embryonic stem cell manipulation and, more recently, CRIPSR/Cas9 have propagated the use of GM mice alongside wild-type strains into a broader range of laboratories than ever before. Our control of genetic manipulations has a grander temporal and spatial range than before and promises to open up new science and avenues for therapeutic discovery. Given the explosion of mouse models that are theoretically and practically possible to generate, it is becoming more critical than ever to define the questions we want to answer and then develop and refine technologies to study and phenotype strains of interest, ultimately to aid translation of experimental mouse data into clinically- relevant developments. Nowhere is this more important than the realm of obesity, metabolism and metabolically- related co-morbidities.

This meeting aims to bring together experts in mouse strains and phenotyping and share their perspectives on mouse phenotyping contributing to advances in obesity, metabolism, and metabolically-related co-morbidities to a broad audience of researchers, students and technicians from both academia and industry. We hope this will stimulate interest in novel and practical applications of mouse phenotyping and facilitate new scientific networks to further research in this space.

This meeting is generously supported by GemPharmatech, Co., Ltd.

Registration slots for this meeting are limited and registrations will be assessed on a first-come first-serve basis.

Details for accessing the seminar via Zoom will be sent out closer to the event day.

Registration

Provisional Program

DETAILS:
Date:
July 6th, 2021

Time:
7:00 am - 12:00 pm (EDT)
12:00 pm - 5:00 pm (BST)
7:00 pm - 12:00 am (Beijing)

Event Category:
External event

Venue:
Via Zoom

For more information, please contact sales@gempharmatech.us

On-Demand Webinars

Germ Free Models Webinar Germ Free Models Webinar

Germ-Free Models for Microbiome Research and Drug Discovery

May 25, 2021

Speakers: Zeyu Jin, PhD and Zhiying Li, PhD

In the last 15 years, the number of publications that referred to germ-free (GF) mouse has risen precipitously, which is mainly caused by more and more interest in the relationship between commensal microbiota and human health.

GF mice are free of all microorganisms in all tissues, which could ensure a clean background for exclusive colonization of defined rnicrobiota or specific strains. And the gold standard to investigate microbiota involvement in a phenotype is to measure the extent to which the phenotype is eliminated under germ-free conditions.

For example, fecal microbiota from patients suffering from different diseases could be transplanted into germ-free mice to check whether the colonization of microbiota could lead to the occurrence of disease, therefore verifying the causal relationships between microbiota and diseases. Combined with different kinds of treatments, we could explore the effects of rnicrobiota on some widely used treatments, one of which is immune checkpoint inhibitor. Besides, the monocolonization of specific strain could examine the physiological influences of this strain and its metabolites on the host.

GemPharmatech (GPT) delivers reliable germ-free mouse models and related services. In the coming webinar, we will share with you the following information:

  1. Brief introduction of germ-free mouse. 
  2. Application of germ-free mouse.
  3. Available germ-free strains and services provided by GPT.

For more information, please contact sales@gempharmatech.us

Germ Free Models Webinar Germ Free Models Webinar

Human Immune System Reconstituted NCG Models For Immunotherapy

April 27th, 2021

Speaker: Pradeep Kumar Sacitharan, PhD

The lack of experimental models featuring a fully functional human immune system is a major obstacle in the evaluation of novel human immunotherapeutics. Gempharmatech developed a series of human immune system reconstituted NCG for immunotherapy research, such as HuPBMC-NCG, HuHSC-NCG. Especially, the HuHSC-NCG-hIL15 can support the colonization and the activity of human NK-cells. The HuHSC-NCG-X can support the red cells reconstitution in bone marrow. In this webinar, we will share experience-based insights to show how the human immune system reconstituted NCG and its derivatives can serve your drug discovery and development process.

This webinar will focus on the following parts:

  1. The human immune system reconstituted NCG for the studies of CAR T-cell therapy
  2. Reconstituted T-cells, NK-cells
  3. GvHD evaluation

For more information, please contact sales@gempharmatech.us

Germ Free Models Webinar Germ Free Models Webinar

Novel Models to Avoid Pitfalls in Immunotherapy

March 30th, 2021

Speakers: Mark Moore, PhD, CEO and Pradeep Kumar Sacitharan, PhD

Immuno-oncolgy is a highly diverse therapeutic area where one in vivo model will not fit all your immunotherapy. Gempharmatech developed a variety of in vivo immuno-oncology models, specifically the humanized mice models. Models are currently available for a range of cancer types including breast, colorectal, lung cancer, lymphoma, melanoma, liver cancer and others. The Checkpoint Humanized Mice models and Humanized Immune Reconstitute Mice models are great models for preclinical drug studying. Which mouse model is fit for evaluating preclinical anti-tumor drugs? Why shall we choose BALB/c background rather than B6 background mice? Models only Evaluate T-cell Targets?

In this webinar, we will share with you the following information around humanized mice models and GPT drug efficacy service:

  1. Why we need to use the Humanized Mice models?
  2. Immune Checkpoint Humanized Mice models.
  3. Humanized Immune Reconstitute Mice models.

For more information, please contact sales@gempharmatech.us

Germ Free Models Webinar Germ Free Models Webinar

Novel Models to Study and Evaluate Drug Development for NASH​

February 23th, 2021

Speakers: Mark Moore, PhD, CEO and Zhiying Li, PhD

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease.

Nonalcoholic steatohepatitis (NASH), an extreme form of NAFLD, affects more than 115 million people around the world. In 2020, a panel of international experts from 22 countries proposed that MAFLD (Metabolic Associated Fatty Liver Disease) is a more appropriate nomenclature for this medical condition. This recommendation is based on the universal presence of hepatic steatosis and one of three other criteria, namely metabolic dysregulation, overweight/obesity or type 2 diabetes mellitus. This new definition reflects the complex nature of this condition, aims to assist the diagnosis and patient stratification, and accelerates the development of therapies through translational research. In the meantime, more pharmaceutical and biotech companies are dedicating their R&D effort to developing new drugs for this disease. GemPharmatech strives to provide quality NASH mouse models to assist this global effort. What characterizes different mouse models for NASH? How to choose a suitable mouse model for your NASH R&D? In this webinar, we will share with you insights on two NASH models and GPT’s drug evaluation and efficacy testing services:

  1. Background of NAFLD/NASH
  2. Classic NASH models
  3. Two novel NASH models and their characteristics

For more information, please contact sales@gempharmatech.us

Germ Free Models Webinar Germ Free Models Webinar

'Knockout All Project' - Why, What and How?

January 26th, 2021

Speakers: Mark Moore, PhD, CEO and Pradeep Kumar Sacitharan, PhD

This webinar will focus on the following parts:

  1. Introduction of GemPharmatech US
  2. Techniques of genome editing and mouse model generation.
  3. What is the KOAP project?
  4. Why can the KOAP project help facilitate your research?

For more information, please contact sales@gempharmatech.us